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Psychiatry

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2 articles
1
Johansson EK, Park S, Okonkwo D
JAMA Psychiatry 83: 401-412
PMID: 39901234DOI: 10.1001/jamapsychiatry.2026.0234
clinical-trialFree ArticleApr 22, 2026
This phase 2b trial compares the efficacy of psilocybin-assisted therapy with escitalopram in adults with treatment-resistant major depressive disorder over 12 weeks.
psilocybindepressiontreatment-resistantpsychedelic therapySSRI
2
Johansson EK, Park S, Okonkwo D
The Lancet Psychiatry 12: 678-690
PMID: 39398765DOI: 10.1016/S2215-0366(25)00198-4
clinical-trialFree ArticleAug 18, 2025
This randomized controlled trial compares intranasal esketamine with quetiapine add-on therapy for acute depressive episodes in patients with bipolar I and II disorder.
esketaminebipolar depressionketamineNMDA receptorrapid-acting antidepressant